• R&D



Erelle ™

Erelle ™ is a Dermal Filler containing cross-linked polymer derived from cellulose, completely resorbable more effective over time compared to currently marketed products.

Why a product based of Carboxymethyl-cellulose?

Carboxymethylcellulose is a biosintetic product, non-animal and non-bacterial. The carbossimentilcellulosa is already used in medicine for many years and is approved for such use by the FDA.
The available literature shows that Carboxymethylcellulose is an extremely safe and inert substance without the phenomena of carcinogenicity or mutagenicity. Some studies show a bactericidal effect inside the tissue, making it extremely safe for these uses.

Why not another product made from hyaluronic acid?

Products based on carboxymethylcellulose (CMC) are an innovative range of injectable implants, increasingly used, because manageable and secure as ialuronici acids but with a bulking effect more effective and longer lasting in time. Crosslinking and the lack of specific enzymes capable of degrade the molecule inside the human body, stabilizes the polymer, giving it a longer life. The value of resistance to mechanical deformation is better than the other products.
The CMC is a Hydrogel that at native state, has specific features of viscosupplementation and drug delivery. These features have been implemented over the last 50 years by the pharmaceutical companies that use CMC as an excipient of high purity for injectable drugs (e.g. Decadron) or as an agent of late (Drug Delivery) for the release of active ingredients (e.g. in Nifedipine a drug antihypertensive).
The CMC is already capable of producing tissue augmentation. For this reason some injectables in the market use CMC as carrier.
With the procedure devised by Bioitech the Crosslinking carboxymethyl cellulose can be injected through thin needles, increasing exponentially the filling performance compared to acid Ialuronici crosslinkati, but keeping the same handling and usability. With the crosslinked CMC were obtained durations as long term products, in total absence of reactive fibrosis tissue, without adverse effects.

Technical characteristics


Type of material
Hydrogels of crosslinked carboxymethyl cellulose in isotonic buffered saline solution pH 7, transparent, injectable, sterile.

Made of pure carboxymethyl cellulose
Absence of other synthetic polymers or synthetic substances added
Hypoallergenic, does not require preliminary tests
Total biocompatibility
Total biodegradability

Homogeneous monophasic Gel in pre filled syringe, devoid of residue.
Easy to inject

Specific features to correct various types of inestesismi
Does not require a specific technique of infiltration
Needles: size 27 G ½ or 30 G ½

Duration of aesthetic correction to other compatible products based on hyaluronic acid, equal to 6-12 months according to the degree of cross-linking.

Key Business Areas

Carboxymethyl Cellulose Platform


Hyaluronic Acid Platform

Syringe Components




© 2012, BIOITECH S.r.l. All right reserved | C.F. e P.I. 10671701000 | Via Chiana, 87 00198 - Roma (Italy)